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Skibicka KP (2013) The central GLP-1: implications for food and drug reward

Even clinicians who are not as familiar with these medications will ask me, 'I have a patient on Mounjaro who's not losing weight can we switch to Zepbound? without realizing its exactly the same drug. To complicate matters, pharmaceutical companies are quickly working on new drugs including triple agonists that target GLP-1, GIP and glucagon receptors as well as oral versions of each drug

Yes and the mechanism is one of the most clearly established in this category

In SURMOUNT-1 (N=2,539), tirzepatide 15 mg produced nausea in 39% of participants

GLP-1 receptor agonists (like semaglutide/Ozempic) and dual GLP-1/GIP agonists (like tirzepatide/Mounjaro) were originally developed to treat type 2 diabetes

Abeer MM, Meka AK, Pujara N, Kumeria T, Strounina E, Nunes R, et al