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no change in the thickness or texture of the skin is typically observed The macules may be present unchanged for many years and some are indistinguishable from a melanoma (a skin cancer type) How is Genital Melanotic Macules Diagnosed

Cocaine-induced ischemia in prefrontal cortex is associated with escalation of cocaine intake in rodents

"Fruit, vegetable, and fish consumption and heart rate variability: the Veterans Administration Normative Aging Study." Am J Clin Nutr 89 (2009): 778-786

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Ito, N., Seki, S., & Ueda, F