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In fact, even factors such as the capsule, which is a crucial virulence factor finely regulated, are associated with multiple ccs and can be present in carriage isolates (Oldfield et al., 2018

Conclusions The serelaxin clinical trials failed to show significance due to several reasons, including patient selection, trial design, and the use of long-term clinical endpoints despite the short serelaxin administration

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doi: 10.1111/cob.12580

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Thomas Garvey, a former FDA official and drug industry consultant who has testified against McNeil in trials, called the amount of time the FDA had taken to reach a final ruling remarkable and unusual. There are still many questions about this drug, Garvey said