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When IGF1 LR3 binds to IGF-1 receptors on target cells, it starts a cascade of intracellular signaling pathways, including the PI3K/Akt pathway and the MAPK/ERK pathway, which regulate protein synthesis, glucose body function, and cell survival mechanisms

PLoS One 2014;9:e103174.ArticlePubMedPMC 89

5 UNCLEAR RELATIONSHIP WITH HORMONES IN WOMEN The relationship between androgens and female pattern hair loss is less clear