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This was carried out using the MannWhitney test for non-related samples and Wilcoxon test for related samples

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Hence, requirements of specific necrosome components may be variable depending on the pathophysiology, with Toll-like receptor 3-mediated necrosis proceeding independent of RIP1 [131] and MLKL-mediated regulated necrosis proceeding independently of RIPK3 in inflammation after Con A-induced hepatitis [132]