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When researchers ran GHK data through the Broad Institutes gene-expression maps, the molecule looked like it shifted the activity of several thousand human genes, on the order of a third of the protein-coding genome in that reference set

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documented that GHK-Cu modulates over 4,000 human genes, including gene sets involved in tissue remodeling, Wnt pathway signaling, and inflammatory regulation

In experimental systems, the combination is studied as a model for examining how complementary peptide signaling pathways influence tissue remodeling and cellular repair responses

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