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Quick Answer: Current evidence suggests a possible association between semaglutide and pancreatitis rather than a confirmed causal relationship, with clinical trials showing relatively low incidence rates

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The downside is that you're layering tirzepatide's GIP effects on top of residual semaglutide (both have ~5-day half-lives, so semaglutide is still present for 2-3 weeks after your last dose)

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