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Discussion In this study, we showed that cryopreserved canine primary hepatocytes in a sandwich culture are an appropriate in vitro model for canine ITZ-associated hepatotoxicity

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In some cases, the target concentration will also depend on the specific therapeutic objectiveeg, the control of atrial fibrillation by digoxin often requires a target concentration of 2 ng/mL, while heart failure is usually adequately managed with a target concentration of 1 ng/mL

Considerations No clinical validation: There is no evidence-based guidance on what is safe or effective in humans

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Can J Biochem