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Semaglutide effects on cardiovascular outcomes in people with overweight or obesity (SELECT) rationale and design

Quantification of GLP-1R-bound cholesterol in both WT and V229A receptors following vehicle versus acute (2 minute) exendin-4 stimulation showed a significant decrease in cholesterol binding to GLP-1R V229A in vehicle conditions without modifying cholesterol binding after agonist stimulation compared to GLP-1R WT (Figure 3D)

Shimomura I, Bashmakov Y, Horton JD

Oncogene 2003

I.SkenandoreC.ZhouZ.et al