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doi: American Diabetes Association Professional Practice Committee

GLP-1R knockout mice (GLP-1R KO, Shanghai Model Organisms, based on C57BL/6N) were generated using CRISPR/Cas9 technology, which causes Glp1r gene protein reading frame shift and loss of function by using non-homologous recombination repair to introduce mutations

Theres some evidence that losing weight too quickly can have some downsides, so slowing it down might help you maintain it later on

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in 2014, a weekly SC formulation was developed, and the indication for weight loss was approved by the FDA

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