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Abbreviations GSH: l-glutathione ATP: adenosine triphosphoric acid -GCS: -glutamylcysteine synthetase GS: glutathione synthetase GGT: -glutamyltranspeptidase PepT: tripeptidase CD: cysteine desulfhydrase CBL: -lyase GBE: glycogen-branching enzyme l-SDs: l-serine deaminases PK: pyruvate kinase PEP: phosphoenolpyruvic acid G6P: glucose 6-phosphate F6P: fructose 6-phosphate PFK: phosphofructose kinase IPTG: isopropyl -D-1-thiogalactopyranoside DCW: dry cell weight 2-DE: two-dimensional electrophoresis TCA: trichloroacetic acid CBB: coomassie brilliant blue EMP: embden meyerhof pathway References Meister A, Anderson ME

Inhibitors, including gossypol (AT-101) and its derivative FX-11, have demonstrated efficacy in preclinical and early clinical studies, while other molecules, such as galloflavin, oxamate, quinoline derivatives and N-hydroxyindole-based compounds, demonstrate potential in suppressing tumor progression (168-173)

Dnmts and Tet enzymes mainly maintain DNA methylation and demethylation patterns 41

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IV Glutathione has faster onset of action compared to the oral glutathione