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Interestingly, the C-terminus of exendin-4 may be required to facilitate formation of high order GLP-1R oligomers through interaction with neighbouring GLP-1R protomers in trans (Koole et al ., 2017)

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Neuroprotective and restorative properties of the GLP-1/GIP dual agonist DA-JC1 compared with a GLP-1 single agonist in alzheimers disease

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The primary measure of effectiveness was the change in glycated hemoglobin A1c (HbA1c) levels, a marker of blood glucose control, from the start of the study to the end of the 26-week period