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Another selenium-containing enzyme, thioredoxin reductase, helps maintain GSH in its reduced and active states within the cell

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The first group function in glutathione homeostasis including amino acid uptake transporters (SLC7A11 and SLC6A9), GSH synthesizing enzymes (-GCLc and -GCLm), GSH metabolizing enzymes that eliminate ROS through GSSG/GSH oxidation-reduction cycle (GPx and GRx) and GSH complementary enzymes such as glutathione transferases (GST)