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Gut microbiota-derived 5-hydroxyindoleacetic acid from pumpkin polysaccharides supplementation alleviates colitis via MAPKs-PPAR/NF-B inhibition

These effects could potentially be beneficial in treating various neurological conditions, though clinical evidence remains extremely limited

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Level 1: identification by retention times (compared against in-house authentic standards), accurate mass (with an accepted deviation of 3 ppm), and MS/MS spectra, Level 2a: identification by retention times (compared against in-house authentic standards), accurate mass (with an accepted deviation of 3ppm)

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However, the evidence is obtained that BPC 157 action initially affects expression of particular genes (i.e., Akt1, Grb2, Nos3, Pik3cd, Prkcg, Ptk2, and Src )