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The modeling process followed the protocol described in previous literature [19]

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We evaluated the effect of low concentrations of RSL3 in combination with either a high or low dose of COJEC on cell viability using the chemoresistant organoid models LU-NB-1 and LU-NB-3R (Figure S4A-B and Table S1)

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Colonic transit test is needed if further work up is necessary for constipation

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