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The challenges of using a copper fluorescent sensor (CS1) to track intracellular distributions of copper in neuronal and glial cells

In addition to characterizing a new family of HGF/Met antagonists, this Example demonstrates a qualitative relationship between the ability of a compound to bind HGF and block HGF dimerization and its observed in vitro biological activity

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The peptides are dispensed per patient, dosed and adjusted at follow-ups

This small molecule, dihexa, penetrates the BBB, induces spinogenesis/synaptogenesis at picomolar concentrations [70] , and is slowly cleared from the blood (plasma stability t 1/2 = 335.5 min) [73]