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The CREDENCE clinical trial evaluated the effects of canagliflozin 100 mg daily versus placebo in 4401 patients with T2DM and chronic kidney disease (CKD)

In the STEP 1 trial published in 2021, participants receiving semaglutide 2.4 mg weekly lost an average of 15.3 kg (about 34 pounds) over 68 weeks compared to 2.6 kg in the placebo groupa difference that captured clinician and patient attention alike

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These factors can lead to oxidative stress, which has been linked to numerous health issues and accelerated aging

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