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Topical KPV and PEPITEM-derived tripeptides have been studied for direct application to affected skin

8 GHRH is a peptide hormone that interacts with a G protein-coupled receptor (GHRHR) in somatotroph cells to activate the cAMP signaling pathway, which leads to increased GH mRNA transcription and release

Pylak et al., 2019

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Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy

Biochemical and histological analyses were performed on the hippocampal and cortical tissue, assessing oxidative stress markers, antioxidant enzyme activity, and glial activation through spectrophotometric assays and immunohistochemistry