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Obesity, insulin resistance, and chronic hyperglycaemia are all associated with increased inflammation and oxidative stress, which can negatively impact brain function

Absence of the biochemical symptoms of essential fatty acid deficiency in surgical patients undergoing protein sparing therapy

Mechanistically distinct compounds have also been reported, including icFSP1, which targets FSP1 through a phase separation-linked mechanism and can synergize with ferroptosis-inducing agents 122

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This appears to form a feedback loop with SAV1, which is sensitive to mechanical force, as previously mentioned