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In the pancreas, semaglutide stimulates insulin secretion in a glucose-dependent manner meaning it triggers insulin release when blood glucose is elevated, but not during normoglycemia, which substantially reduces the risk of hypoglycemia compared to older antidiabetic agents

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Clinical Effectiveness and Expected Results In clinical trials, patients taking Wegovy experienced significantly more weight loss than those on lifestyle modification alone

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Assess for ketoacidosis regardless of presenting blood glucose levels in patients who present with signs and symptoms consistent with severe metabolic acidosis