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The pivotal Phase 2 trial (NCT04881760), published in The New England Journal of Medicine (Jastreboff et al., 2023), enrolled 338 adults with BMI 30 or higher

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Importantly, this catalytic tetrad is conserved among all the seleno-GPxs (GPx1, GPx2, GPx3, GPx4, and GPx6) characterized from human (Table 1

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