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The increase in cAMP levels in -cells is a consequence of GLP-1R activation in these cells, which in turn enhances the secretion of growth inhibitory hormone through signaling pathways such as PKA and Calcium/Calmodulin-dependent protein kinase (Brereton et al., 2015)

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References: Charbonnel B, Cariou B (2011): Pharmacological management of type 2 diabetes: the potential of incretin-based therapies

Side effects often return briefly with each dose increase but typically at a milder level than the initial adjustment period

Ocular complications from glucagon-like peptide-1 receptor agonists: Clinical evidence, potential mechanisms, and clinical recommendations

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