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the specific escalation steps and intervals were defined by the trial protocol

Additionally, lysosome-associated membrane protein 3 (LAMP3) is elevated within the salivary glands of specific individuals suffering from SS, and the resulting lysosomal dysfunction serves as a crucial factor in the evolution of the disease [280]

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Wilding JPH, Batterham RL, Davies M, Van Gaal LF, Kandler K, Konakli K, et al

J Pharmacol Exp Ther 2002, 300: 958966