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Localized injection site reactions are common and usually not dangerous

While animal models especially mouse such as diet induced, deficiency induced, toxin induced, genetically induced or as a mixture of these modalities have provided foundational insights into the mechanisms of MASLD and MASH, the translation of these findings to human pathophysiology remains limited due to significant biological and metabolic disparities between species (295, 296)

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This dual action means injection near a specific wound provides high local concentration while the peptide also circulates and may accumulate at other injury sites throughout the body