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Aloe vera contains Aloin, a compound that can help lighten pigmentation over time
These were, i.e., in the cerebellum (ibuprofen [107], paracetamol [61]), the cerebral cortex (diclofenac [106,108], celecoxib [105]), the frontoparietal cortex (concussive brain trauma) [78], the hippocampus and the cerebral cortex (insulin) [62], and the parietal neocortex and hippocampus (cuprizone [80]) (note, cuprizone application [80] was an extremely high regimen highly over those commonly applied to mimic multiple sclerosis in rats [268,269])
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Although it has been used in an animal models, there are distinct challenges that impede shikonin moving forward as a widely antimicrobial therapeutic agent such as poor solubility
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2011 Nov;1812(11):1412-7
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