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It has been the subject of extensive preclinical research examining pathways involved in angiogenesis, growth-factor signalling and connective-tissue models

While direct cortisol measurements were not specifically reported in the published safety trials, the comprehensive metabolic monitoring across 900+ participants showed no clinically significant hormonal changes, and the mechanism of action provides no pathway for cortisol stimulation

*Nutrients*, 5(11), 4284-4304

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