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Sex stratification is essential: female rodents have approximately 3040% higher basal follistatin levels and blunted myostatin expression relative to males, producing sex-dimorphic responses to both agents

Review for any drug-drug interactions (especially with valproic acid, phenobarbital, or phenytoin)

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The medication significantly reduces hunger and cravings, making lifestyle habits easier to maintain but those habits remain an essential part of the outcome equation