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Aside from the infrequent occurrence of postnatal thyrotoxicosis due to maternal antibodies, the incidence of spontaneous GD in children before the age of ten is unusual, but the incidence climbs with each decade until about age 60 (16-20)

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Ann Dermatol Venereol 2002

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In the case of oxidative stress, JNK increases the phosphorylation of SARM1, resulting in enhanced NAD + degradation activity, which in turn promotes the suppression of mitochondrial respiration