It belongs to a wider set of peptides moving through longevity and biohacker circles, including BPC-157, Cerebrolysin, Semax, Selank, Dihexa, P21, and the neurotrophic factors BDNF and klotho, whose human cognitive evidence ranges from thin to absent and which I reviewed in detail here
Certainly, differences during the second and third hour after meal stimulation as reported by Toft-Nielsen et al
PCa cells exhibit upregulated tryptophan-hydroxylating enzymes and aromatic L-amino acid decarboxylases, key drivers of tryptophan metabolic reprogramming
By age 60, those levels drop to approximately 80 nanograms per milliliter
A study published in the Journal of Pineal Research documented the decline in pineal melatonin production in relation to Alzheimer disease progression
The science supports this and so does my own personal journey - I was on Mounjaro for 6 months - lost over 30kg and Ive kept it off for longer than I was on Mounjaro - but the key is that I used this to start intermittent fasting, consistent exercise (which was much easier as the weight was coming off) and I learned to eat better
