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doi: 10.1038/nrendo.2012.140

Evidence (selpercatinib): A phase I/II trial (LIBRETTO-001 [NCT03157128]) evaluated the safety and efficacy of selpercatinib in adolescent and adult patients with any solid tumor type harboring an activating RET alteration

Among these, five (55.5%) demonstrated reductions in total daily insulin requirements

Approval status is night and day: tirzepatide is FDA-approved (Mounjaro in 2022, Zepbound in 2023), while retatrutide is still working through Phase 3

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