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4-HNE in high concentrations is one of the most toxic and mutagenic metabolites of lipid peroxidation for the cell ( Another important signalling metabolite that is generated through the cyclooxygenase-mediated peroxidation of PUFAs is malondialdehyde (MDA)

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Proc Natl Acad Sci U S A 101:37805, PMID: 15004285 Townsend DM, Manevich Y, He L, Hutchens S, Pazoles CJ, Tew KD (2009) Novel role for glutathione S -transferase pi Regulator of protein S-glutathionylation following oxidative and nitrosative stress

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Pyridoxal phosphate prevents progression of diabetic nephropathy

Neurol.Sci 2010;31(1):61-64