doi: 10.1002/j.1550-8528.1994.tb00636.x 139 KhanSJenaG
Because it works by affecting hormones that regulate appetite, digestion, and blood sugar levels, some individuals may experience side effects, particularly during the early stages of treatment
A total of 19.7% of the participants in the tirzepatide group had a reduction in body weight of at least 30% (an exploratory end point) as compared with 6.9% of those in the semaglutide group, which indicated that the likelihood of meeting this weight-reduction target with tirzepatide was 2.8 times as high as that with semaglutide
Anecdotal reports from patient forums occasionally mention worsening of histamine-related symptoms after starting Mounjaro, but such observations have not been validated through controlled studies and cannot establish causality
Your bodys fat cells become less inflamed
So its a case of leapfrogging and iterative improvement