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The poor permeability and the function of the BBB arise from its structure: tightly packed endothelial cells, supported by astrocytes and pericytes, shield the brain from toxins and pathogens

56 Therefore, BDNF reduction in the vSUB can cause deficits in reward function and induce anhedonia

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Within hours of administration, BDNF and its receptor TrkB increase in the hippocampus