Design Phase 3, double-blind, randomised, placebo-controlled Duration 72 weeks (20-week titration + 52-week maintenance) Arms Tirzepatide 5 mg, 10 mg, 15 mg, placebo (1:1:1:1) Lifestyle All arms received counselling on diet and physical activity Sponsor Eli Lilly & Company Reference Jastreboff AM et al
In addition, we discuss the increase in the endogenous secretion of this hormone through various stimuli (e.g., carbohydrates, proteins, gut microbiota, bacteria-derived molecules, bile acids, lipids, fatty acids, polyphenols, etc.) or by the increase of GLP-1-producing cells, i.e., L-cells, which can be an appropriate approach for the management of diabetes
Understanding how these three signalling axes interact is central to current metabolic research and forms the primary basis for ongoing investigational study of this compound
That means most people are left footing the bill
The medication is administered as a once-weekly subcutaneous injection and is currently in phase 3 clinical trials, with FDA approval potentially on the horizon pending trial outcomes
There is also great potential for GLP-1s in managing risk of obstructive sleep apnea during the perimenopausal period