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MK-677 has been employed primarily in studies requiring sustained, measurable elevation of circulating IGF-1 over weeks to months

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(ii) Stratification and Long-term Follow-up of Maternal-Fetal Outcomes: Short-term outcomes (miscarriage, preterm birth, structural malformations, placental complications, fetal growth abnormalities) and mid-to-long-term outcomes (offspring growth trajectories, metabolic phenotypes) must be pre-defined within a standardized follow-up framework to assess potential metabolic programming risks

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doi: 10.1016/S0304-3835(01)00834-5

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