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As a result, that broader profile may contribute to both effectiveness and adverse-effect differences, but direct human receptor-selectivity comparisons are incomplete

Food and Drug Administration PubMed 11

Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression

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This is the immune system recognizing the modified peptide as foreign and mounting a response against it