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Darby, S

However, the physiological half-life of GLP-1 in circulation is very short (less than 2 min), which can be attributed to both rapid proteolytic cleavage of the amide bond of alanine at position 8 (Ala8) in the N-terminus by ubiquitous dipeptidyl peptidase IV (DPP-IV), which results in the removal of the two N-terminal amino acids leading to the formation of a truncated inactive form 10,11 and clearance by the kidney as well

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Quality pharmaceutical-grade injectable programs require investment in proper sourcing, testing, and medical oversight that establishes a price floor below which quality becomes questionable

In this study, we analyzed administrative data from Lombardy, the most populous Italian region, with the aim to evaluate in-hospital outcomes in patients hospitalized with AMI according to their DM status and their anti-hyperglycemic therapy at the time of hospitalization