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3.3.4 MGBA alterations and pathophysiological mechanisms in anxiety Rodent models of anxiety disorders provide causal evidence that stress exposure disrupts the MGBA, leading to microbiota alterations, compromised gut barrier integrity, immune activation and neurotransmitter imbalance (Tyagi et al., 2025) and humid heat environment stress models (Weng et al., 2024) Enrichment of the phylum Proteobacteria was observed across multiple stress paradigms (Jia et al., 2024

Current international guidelines advocate for a Barcelona Clinic Liver Cancer (BCLC)-based treatment algorithm for managing HCC (84)

studied the effect of APAP in rat brain using a wide range of single doses (5 500 mg/kg)

The pathway activates PI3K/Akt/Nrf2 signaling in neural tissue

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