In diabetic NAFLD populations, Godex treatment for 12 weeks significantly improved liver enzymes (56), and L-carnitine monotherapy for 3 months similarly enhanced hepatic function in type 2 diabetes patients with NAFLD (66)
[56] In May 2010 the Norwegian tabloid daily Verdens Gang published a story based upon a report by the Norwegian Pharmacy Association stating that 10,000 syringes are sold annually to Norwegian users of melanotan-1 and melanotan II
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Additionally, a 3-year prospective study involving 1274 patients with modestly controlled T2DM reported that treatment with dapagliflozin or canagliflozin was linked to significant neuroprotective effects
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Based on these studies, elevated C2, C3-DC, C4, or C5 imply impaired metabolism of BCAAs and/or metabolic inflexibility, therefore, supporting their use as potential early biomarkers of the onset of PRIS that could be incorporating into a therapeutic monitoring strategy for propofol [97,98,99,131]
