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Furthermore, activation of hGPR17L with the agonist MDL29,951 resulted in concentration-dependent inhibition of forskolin-stimulated cAMP with a 29 nM IC 50 (pIC 50 = 7.540.11) and maximum inhibition of 375.1% at 390 nM MDL29,951

At the 12 mg dose, nausea was reported by approximately 45% of participants

Available at: Jastreboff AM, Kaplan LM, Fras JP, Wu Q, Du Y, Gurbuz S, et al

Aoki R, Kamikado K, Suda W, Takii H, Mikami Y, Suganuma N, et al

Approved options already exist for many patients

Patients are advised to use only FDA-approved drugs obtained through licensed pharmacies and consult their healthcare provider about any concerns