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And even with the immense amount of innovation and R&D dollars being poured into this market, additional challenges remain: Side effects and tolerability concerns remain substantial

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IM requires a longer needle and a different technique

From a histological point of view, atypical tumor glands, constituted by neoplastic epithelial cells, occur in dense desmoplastic stroma, a proper physical barrier promoting tumor growth and progression and contributing to hamper anti-tumoral response and therapeutics delivery [11,12,13,14]

This changed with recent legislation and the announcement of the BALANCE (Better Approaches to Lifestyle and Nutrition for Comprehensive health) Model in December 2025, which creates a Medicare GLP-1 payment demonstration scheduled to begin in July 2026