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J Clin Invest 2013;123:27302736.ArticlePubMedPMC 109

804 Gene therapy Advances in sequencing technologies and bioinformatics tools have greatly enhanced our understanding of the genetic origins of inherited disorders

Semaglutide, a medication often used to treat type 2 diabetes and aid in weight loss, has been reported to cause gastrointestinal side effects in some individuals

GLP-1s alter taste perception and commonly disrupt the perception of sweetness, bitterness, fatty foods and even mouthfeel, especially during early treatment phases, says the firm, which has been conducting ongoing research into the food preferences of consumers on the weight loss and diabetes management medications

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Very long-term continuous use (months to years) is not well-characterized and should be undertaken only with appropriate oversight, full tracking, and clear research objectives that justify the extended duration