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Enter semaglutide, branded as Ozempic, which could be injected just once a week

Introduction Type 2 diabetes mellitus (T2DM) stands as a prevalent metabolic disorder on a global scale, predominantly originating from a dual interplay of two factors: insufficient production of insulin by the cells of the pancreas and the reduced responsiveness of insulinsensitive tissues to insulin [1, 2]

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Clinical trials of GLP-1 receptor agonists have shown average reductions in daily energy intake of roughly 2030% during early treatment phases , reflecting the combined effects of increased satiety and reduced food preoccupation

However, GLP-1 is also produced by enteroendocrine L-cells and by PPG neurons of the lower brainstem

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