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For high-fat diet experiments, mice were fed a 60 kcal% fat high-fat diet (Research Diets, D12451i) following either tamoxifen or AAV-TBG-Cre injection for 2-3 weeks

KPV is a tripeptide that has been demonstrated to be effective in the treatment of various medical conditions such as hypertension, chronic pain, and asthma

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These studies should explicitly address whether -3 PUFAs offer disease-modifying effects by incorporating advanced imaging biomarkers of cartilage integrity

Improper mixing may cause unstable solutions with reduced biological effectiveness