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The Journal of nutrition

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Phase 2 clinical data shows a clean linear dose-response relationship, with each dose tier producing approximately 3 additional percentage points of weight loss

DN2 B-cell: DN2 cells, characterized by the absence of CD27, IgD, and CXCR5 expression but the presence of CD11c, are expanded in SLE patients with severe disease, including nephritis and hyperresponsiveness to TLR7 signaling, which leads to plasmablast differentiation and autoantibody production

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