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The established recycling of HPX is inconsistent with LRP1-mediated endocytosis that leads to the lysosomal degradation of HPX ( / PEA 13 cells (Smith, 2011) and, as reported here, in HL-60 cells that lack LRP1

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She says that future clinical trials might also investigate the benefits of adding dasatinib, which is currently used in leukemia, at lower doses and intermittently to determine its safety and efficacy in periodontal applications

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Does this mean timing doesn't matter