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Some patients may experience alternating constipation and diarrhea, which could create a cycle of irritation and pressure changes in the anorectal region

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Appetite suppression typically increases gradually during the 1620 week dose escalation period, with maximal effects usually emerging after reaching and maintaining the 2.4 mg weekly dose for several weeks

Blood pressure reductions of 3-5 mmHg systolic occur through weight loss and direct vascular effects