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132 The fourth class of co-activators, known as the secondary co-activators, interacts with transcription factors and function as scaffolding non-enzymatic proteins to recruit other co-activators containing enzymatic activities on the target gene promoter

If H 2 O 2 remains in the mitochondrial matrix it reacts with the ferrous (Fe 2+ ) iron via the Fenton reaction yielding the hydroxyl free radical which is highly reactive toward DNA and polyunsaturated fatty acids (PUFA)

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Vitamin D has been also shown to modulate MAO expression, decreasing oxidative stress in neural [64, 65] and cardiovascular tissues [12]

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