Some are similar in action of the vasoactive intestinal peptide (VIP), which relaxes smooth muscle and regulates water and electrolyte secretion between the small and large intestines
These mechanisms occur within hours after GCs administration and may lead to hyperglycemia, even in individuals without a prior history of glucose abnormalities ( Figure 1 The clinical impact of hyperglycemia during GCs therapy has been well established, with multiple studies reporting increased morbidity and mortality, including higher rates of infection, cardiovascular events and prolonged hospitalisations ( Although glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are not currently recommended in SID by major guidelines, their mechanism of action makes them promising candidates to counteract the metabolic impacts of steroids
Traditional dogma asserts that GST functions to catalyze glutathione (GSH)-substrate conjunction to preserve the macromolecule upon exposure to oxidative stress, thus defending cells against various toxic compounds
Insurance companies and compounding pharmacies will not dispense these medications together without explicit written approval from a cardiologist or endocrinologist, and most physicians refuse to authorize such combination therapy
What it will not cover is at-home self-injection, because we do not endorse it and the legal picture around unregulated peptide sources is a mess
Women at this stage of life often carry elevated cardiovascular risk, reduced bone density, and varying degrees of insulin resistance
