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In taste buds, GLP-1 is locally produced from proglucagon through the cleavage by prohormone convertase PC1/3, which is co-expressed with GLP-1 in all taste cells positive for this peptide
The biggest factors are which medication you choose, the dose you reach as you titrate, whether you use brand-name or compounded medication, and your insurance
Acknowledgements We acknowledge support from National Institute on Alcohol Abuse and Alcoholism (AA029831), National Institute on Aging (AG057557, AG061388, AG062272, AG07664), from National Cancer Institute Case Comprehensive Cancer Center (CA221718, CA043703, CA2332216)
Patients who completed adequate semaglutide titration, achieved partial but insufficient weight loss, and are looking for the next pharmacologic step benefit directly from tirzepatide's added GIP receptor mechanism
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